Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex
Abstract Tuberous sclerosis complex (TSC) is a neurogenetic disorder associated with epilepsy, intellectual disabilities, and autistic behaviors.These neurological symptoms result from synaptic dysregulations, which shift a balance between excitation and inhibition.To decipher the synaptic substrate of hyperexcitability, we examined pan-neuronal Ts